Is It Possible to Diagnose Parkinsonism with The Help of Neurosteroids?

Abstract

This article presents information and results of studies on the role of the hormones cortisol and dehy-droepiandrosterone sulfate (DHEAS) in the diagnosis of cognitive impairment and dementia in Parkin-son's disease. The reasons for the relationship of cognitive impairment in Parkinson's disease are de-scribed in detail in comparison with the results of neuropsychological tests. We examined 40 patients with PD, who were divided into 20 patients depending on the presence or absence of cognitive impair-ment and dementia. As a control, we also examined on a voluntary basis 20 healthy persons recognized as such by a special commission. The diagnostic efficacy of neurosteroids has been established, includ-ing the level of dehydroepiandrosterone sulfate and cortisol in the blood serum of patients for early diag-nosis of cognitive impairment and monitoring the effectiveness of therapy, identifying a risk group in PD. R