Relationship Between MTHFR Gene rs1801133 and rs1801131 Polymorphisms With Disease Severity Of COVID-19 And Homocystein Levels In Uzbek Patients

Babadzhanova, Shaira Agzamovna; Kurbonova, Zumrad Chutbaevna; Inoyatova, Feruza Khidoyatovna

dc.contributor.author	Babadzhanova, Shaira Agzamovna
dc.contributor.author	Kurbonova, Zumrad Chutbaevna
dc.contributor.author	Inoyatova, Feruza Khidoyatovna
dc.date.accessioned	2022-10-14T09:38:00Z
dc.date.available	2022-10-14T09:38:00Z
dc.date.issued	2022-10-03
dc.identifier.other	DOI: 10.47750/pnr.2022.13.S01.225
dc.identifier.uri	http://repository.tma.uz/xmlui/handle/1/4147
dc.description.abstract	As a result of endothelial cell alteration and cytokine storm induced by SARS-CoV-2, the causative agent of COVID-19, hypercoagulopathy occurs during the course of the disease. Unfortunately, as a result of this, patients suffering from COVID-19 are suffering from severe and fatal conditions due to the occurrence of thrombosis in vital organs. Therefore, the study of the MTHFR gene A1298C (rs 1801131), C677T (rs 1801133) polymorphisms in the Uzbek population and the significance of the C (rs 1801131) and T (rs 1801133) minor alleles of this gene in the pathogenesis of COVID-19 and in patients with hyperhomocysteinemia It is important to assess the extent of the disease of COVID-19. By identifying this, it is possible to prevent various serious complications that can be caused by COVID-19 by selecting those who have a tendency to develop the disease in a severe form, and by carrying out special prophylactic and therapeutic procedures.	en_US
dc.language.iso	en	en_US
dc.publisher	Journal of Pharmaceutical Negative Results	en_US
dc.relation.ispartofseries	13;
dc.subject	MTHFR, polymorphism, rs 1801131, rs 1801133, wild allele, minor allele folate cycle, hyperhomocysteinemia, endothelial dysfunction	en_US
dc.title	Relationship Between MTHFR Gene rs1801133 and rs1801131 Polymorphisms With Disease Severity Of COVID-19 And Homocystein Levels In Uzbek Patients	en_US
dc.type	Article	en_US