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The Role and Place of Nitroxidergic Regulation of The Endothelial System in the Pathogenesis of Acute Lung Abscess

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dc.contributor.author Охунов Алишер Орипович, Бобокулова Шохиста Абдуалимовна
dc.date.accessioned 2022-11-29T03:25:10Z
dc.date.available 2022-11-29T03:25:10Z
dc.date.issued 2022-11-23
dc.identifier.issn 2577 - 8005
dc.identifier.uri http://repository.tma.uz/xmlui/handle/1/4694
dc.description.abstract Background: Purulent-destructive lung diseases remain a priority among the causes of generalized infection and death. The key to the progression of infection in acute lung abscesses may be associated with impaired barrier-filtration function of this organ, which is based on endothelial dysfunction. Method: The experiments were carried out on 32 Chinchilla rabbits, in which the model of acute lung abscess was reproduced. Investigated in blood samples at the entrance and exit from the lungs, such indicators as nitrates, nitrites, peroxynitrite, NO-synthase and von Willebrand factor. Conclusion: Nitric oxide produced because of iNOS activation is intended for non-specific protection of the body against a wide range of pathogenic agents, inhibits platelet aggregation and improves local blood circulation. However, these changes do not occur. The main role in this direction is assigned to peroxynitrite, which, due to its pathogenicity, worsens the already process associated with endothelial dysfunction. The nature of the changes in the parameters of the nitroxidergic regulation of the endothelial system in the lungs has a staging: compensated and decompensated. All this is of a natural nature, based on certain relationships between the indicators of the nitroxidergic regulation system en_US
dc.language.iso en en_US
dc.publisher Европа en_US
dc.subject Endothelial Dysfunction, Experimental Simulation, Generalization of Inflammation, Inflammation, Lung Abscess, Lung Barrier Function, Nitroxidergic Regulation System en_US
dc.title The Role and Place of Nitroxidergic Regulation of The Endothelial System in the Pathogenesis of Acute Lung Abscess en_US
dc.type Article en_US


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