Influence of polymorphism C3435T MDR1 gene to methotrexate resistance in patients with rheumatoid arthritis

Nargiza Abdurakhmanova, Khalmurad Akhmedov

dc.contributor.author	Nargiza Abdurakhmanova, Khalmurad Akhmedov
dc.date.accessioned	2020-03-04T06:01:55Z
dc.date.available	2020-03-04T06:01:55Z
dc.date.issued	2019
dc.identifier.uri	http://repository.tma.uz/xmlui/handle/1/496
dc.description.abstract	In our study, 120 patients with rheumatoid arthritis and 30 practically healthy volunteers took part. Polymorphism of the C3435T gene was determined using the polymerase chain reaction (PCR), which was carried out in a 7500 Fast Real Time PSR Systems (USA) amplifier. Results: According to the results of our studies, methotrexate resistance was detected in patients with CC genotype C3435T polymorphism of the MDR1 gene. In contrast, carriers of TT genotype showed high sensitivity to treatment and low disease activity. The interrelation of the C3435T polymorphism of the MDR1 gene with the presence of resistance to methotrexate treatment in patients with RA was established. Conducting genotyping of patients with rheumatoid arthritis before the appointment of methotrexate makes it possible to predict the presence of resistance to this drug.	en_US
dc.language.iso	other	en_US
dc.relation.ispartofseries	УДК;
dc.subject	Keywords MDR1, C3435T, methotrexate, rheumatoid arthritis, genotype, polymorphism	en_US
dc.title	Influence of polymorphism C3435T MDR1 gene to methotrexate resistance in patients with rheumatoid arthritis	en_US
dc.type	Article	en_US