CLINICAL FEATURES OF THE COURSE OF ASSOCIATED ARTHRITIS WITH HCV INFECTION AND THE ROLE OF CYTOKINES IN DIAGNOSTICS

Abstract

Currently, more than a dozen pathologies associated with HCV have been described, including lesions of the joints, muscles, circulatory system, salivary glands, eyes, pancreas, nervous system, kidneys, etc.. HCV is much more than a simple liver infection. Extrahepatic manifestations are clinically apparent in approximately 40-70% of patients and may involve many organs. These mainly include joint disorders (arthritis or arthralgia), mixed cryoglobulinemia, small and medium vessel vasculitis, glomerulonephritis, lichen planus, B-cell lymphoma, and cutaneous porphyria. Currently, great importance is attached to the diagnosis of HCVaA. Non-invasive diagnostic methods are most effective for determining the early stage of the disease, so the formation of a target group at risk of developing HCVaA using reliable biomarkers of extrahepatic manifestations of hepatitis is a priority. Recently, the management of patients with HCVaA has been Actively studied. However, in our country, there are few scientific works devoted to the study of the prevalence, diagnosis and treatment of HCV-associated rheumatic manifestations. This work was aimed at assessing the frequency of detection of arthritis in patients infected with HCV (HCVaA), as well as to analyze the identified features of its manifestations using clinical research methods in this category of patients.