THE GENETICS OF HYPERURICEMIA AND GOUTY NEPHROPATHY

Rakhmatov A. M. Jabbarov O. O. Kodirova Sh. A. Tursunova L. D. Jumanazarov S. B. Mirzaeva G. P. Buvamukhammedova N. T. Tojiboev M.S.

dc.contributor.author	Rakhmatov A. M. Jabbarov O. O. Kodirova Sh. A. Tursunova L. D. Jumanazarov S. B. Mirzaeva G. P. Buvamukhammedova N. T. Tojiboev M.S.
dc.date.accessioned	2022-12-21T06:53:10Z
dc.date.available	2022-12-21T06:53:10Z
dc.date.issued	2022
dc.identifier.uri	http://repository.tma.uz/xmlui/handle/1/5403
dc.description.abstract	Gout is a common joint disease caused by hyperuricemia. This article provides new information on the genes that cause gouty nephropathy, including the results of genomic studies. Most gout-related genes are involved in the renal urate transport system. For example, the urate carrier genes SLC2A9, ABCG2, and SLC22A12 modulate uric acid levels and hence the risk of developing gout. SLC2A9 and SLC22A12 genes provide the balance of uric acid absorption and secretion in the kidneys. It is here that mutations in these genes upset this balance.The discovery of these genes greatly expands our understanding of the role of urate carriers in the pathogenesis of gout.	en_US
dc.language.iso	en	en_US
dc.publisher	Web of scientist:international scientific research journal	en_US
dc.subject	gout, gouty nephropathy, gene, GWAS	en_US
dc.title	THE GENETICS OF HYPERURICEMIA AND GOUTY NEPHROPATHY	en_US
dc.type	Article	en_US