EVALUATION OF THE EFFECTIVENESS OF CLOMIPHENE CITRATE CONTAINING SUBSTANCES IN STIMULATION OF OVULATION IN WOMEN OF LATE REPRODUCTIVE AGE WITH LOW OVARIAN RESERVE

Abstract

Objective: to evaluate the effectiveness o f the use o f clomiphene citrate-containing drug in ovulation stimulation in women o f late reproductive age with low ovarian reserve. Materials and methods. The study included 60 women with reduced ovarian reserve, o f which: 1 - the main group included -3 0 women with low ovarian reserve and II - 30 women with extremely low ovarian reserve treated with clomiphene citrate containing a drug for ovarian stimulation, the comparison group consisted o f - 20 women with a similar pathology, but refused to take a clomiphenecontaining drug. All patients were prescribed clomiphene citrate containing substances to stimulate ovulation. The assessment o f the ovarian reserve in women was carried out by assessing its biochemical and echographic markers. Results. In group I patients, ovulation was achieved in 23 (76.7%) patients. O f these, 2 (11.7%) ovulated after the second cycle at a dose o f 100 mg and in 5 (29.4%) after the third month o f ovulation at a dose o f 150 mg o f clomiphene citrate-containing drug per day. Pregnancy occurred in 15 (73.0%) patients o f this group: in one patient in the first cycle o f treatment when taking 50 mg o f clomiphene citrate-containing preparation, in the second in the third cycle o f ovulation stimulation at a dose of 00 mg o f this drug. In the 2nd group o f patients, ovulation was achieved in 21 (70.0%>) patients. Three (10%) and two (6.7%>) o f them ovulated after the second and third months o f stimulation using 100-150 mg o f clomife-containing drug per day. Pregnancy occurred in 15 (66.7%>) patients o f this group. Pregnancy in the comparison group occurred in 3 (15.0%) patients. Conclusion. The use o f clomiphene citrate-containing drug in women from late reproductive age with low and extremely low ovarian reserve leads to the induction o f ovulation in 76.7% and 70.0% o f women, and the onset o f pregnancy in 73.0% and 66.7% o f women, respectively.