Experimental substantiation of the use of hypoxia-inducible factor (HIF-1α) for the development of toxic hepatitis.

Kurbonova Z.Ch., Sayfutdinova Z.A., Muhammadiev X.G., Xashimova G.T

dc.contributor.author	Kurbonova Z.Ch., Sayfutdinova Z.A., Muhammadiev X.G., Xashimova G.T
dc.date.accessioned	2023-01-28T04:43:54Z
dc.date.available	2023-01-28T04:43:54Z
dc.date.issued	2022-10
dc.identifier.uri	http://repository.tma.uz/xmlui/handle/1/6140
dc.description.abstract	This article provides an experimental justification for the use of hypoxia-inducible factor (HIF-1α) on the development and course of toxic hepatitis based on heliothrin intoxication. Acute heliothrin intoxication was reproduced by a single subcutaneous injection of a sublethal dose of heliothrin, prepared at the rate of 40 mg per 100 g of body weight, to rats. During the reproduction of experimental toxic hepatitis by the administration of heliothrin, it was found that the content of HIF-1 was on average equal to 0.101667±0.0022 ng/l. In blood plasma, mean HIF1 levels were 0.2136±0.0066 ng/l.	en_US
dc.language.iso	en	en_US
dc.publisher	Инновационное развитие науки и образования 2022	en_US
dc.relation.ispartofseries	doi.org/10.5281/zenodo.7353873;
dc.subject	hypoxia-inducible factor; heliotrin intoxication; experimental toxic hepatitis; aryl hydrocarbon receptor transolator.	en_US
dc.title	Experimental substantiation of the use of hypoxia-inducible factor (HIF-1α) for the development of toxic hepatitis.	en_US
dc.type	Article	en_US