How does Lipid Peroxidation Affect the Development of Pneumosclerosis: Experimental Justification

Abstract

Background. Pneumosclerosis is a frequent complication of chronic obstructive pulmonary disease, bron chial asthma, and chronic obstructive bronchitis. The development of these complications aggravates the course of the disease, worsens its prognosis, leads to an increase in the duration of inpatient treatment, and significantly worsens the quality of life of patients, especially in terms of age. Methods. The experiments were carried out on 25 laboratory rabbits with a pneumosclerosis model. The intensity of lipid peroxidation in the lungs was assessed in terms of malondialdehyde and chemilumines cence intensity in blood samples obtained in various blood samples. Results. The dynamics of the development of pneumosclerosis was characterized by an increase in the intensity of lipid peroxidation in the lungs. The intensity of these processes was expressed to a greater extent in the arterial blood sample, indicating the specificity of the identified changes for this pathological process. An increase in the intensity of chemiluminescence in arterial blood on the 10th day of pneu mosclerosis development was noted by 3.6 times, and on the 20th day - by 3.3 times compared with the control values. Even in the long-term studies, this indicator was 1.7 and 2 times higher than the control values and was more pronounced than in venous blood. Conclusion. Reproduction of the experimental model of pneumosclerosis is characterized by the intensity of lipid peroxidation processes to a greater extent in the lungs than in other organs not affected by the pathological process. These changes were identified using a separate assessment of the level of lipid pe roxidation in venous and arterial blood with the calculation of the venous-arterial difference. At the same time, more pronounced changes were noted in relation to the chemiluminescence index, indicating a high role of free radical compounds in the formation of this pathological process.