The Course of Juvenile Idiopathic Arthritis and Kidney Damage

Abstract

The study of the course of juvenile idiopathic artritis (JIA), determination of disease activity, duration, number of affected joints and target organs improved the understanding of the pathogenesis of the disease and made it possible to better characterize the reliability of use in therapy. The aim of the study was to research various variants of the course of JIA and kidney damage.Tested 38 patients aged 3 to 17 years with JIA and a questionnaire, clinical, anamnestic and laboratory-instrumental examination were conducted. Results of the study showed that 29-76.3% patients characterized criteria as arthritis lasting 3 months or more, morning stiffness, arthritis of the second joint that arose after 3 months and later, symmetrical damage to small joints, effusion into the joint cavity. In 28.9% patients, a persistent variant of oligoarthritis was noted, and progressive oligoarthritis occurred in 71% of the examined patients. In 60.5% patients, the disease proceeded with kidney damage. The duration of the course in JIA in children ranges from 3 months to 8 years, large and medium joints are more often affected - knee, ankle, wrist, elbow, hip. The exudative component of 39% is less pronounced in boys, productive-dystrophic changes of 61% in the joints of the lower extremities predominate. In girls, exudation in the joints of the upper extremities prevailed - 85%. Kidney damage in the form of nephritis was observed in 60.5%, microalbuminuria - in 13.2%, an increase of creatinine data in the blood – 68%.