Morphological Characteristics of The Lung Tissue in The Reproduction of a New Experimental Model of Acute Lung Abscess Against the Background of Diabetic Microangiopathy

Abstract

A morphological study of lung tissue in animals with an experimental model of acute purulent-destructive lung disease on the background of diabetic angiopathy was carried out. It has been established that in the initial phase of modeling purulent inflammation against the background of diabetes mellitus, diffuse plethora of blood vessels, disorganization of their walls, development of edema and perivascular hemorrhage, leukocyte infiltration of the interalveolar septa and the appearance of foci of confluent inflammation and distelectasis of the lung tissue are noted. On the 7th day after modeling the pathological process, there is an increase in dyscirculatory, destructive and inflammatory processes in the form of paralytic expansion of the vascular wall due to fibrinoid swelling, increased migration of leukocytes into the lung tissue, the development of destruction, the formation of microabscesses, compaction of the lung tissue due to interstitial inflammation and distelectasis . Diabetic angiopathy leads to the development of mild dystrophic and destructive changes in the tissue structures of the lung, which, when modeling a purulent process, are combined with destructive and inflammatory processes, leading to massive damage to the lung tissue in the form of a complete structureless destruction of the lung tissue, the formation of diffuse and focal purulent inflammation, in particular abscesses. In the later stages after the modeling of a purulent process in the lung, the formation of a limited round and oval shape of abscess foci is noted against the background of the preservation of dystrophic and sclerotic changes in the lung tissue due to diabetes mellitus. At the same time, foci of abscess formed between the lung segments, in the area of localization of large vessels and bronchi.