The role of mdr1 gene polymorphism in the duration of remission of rheumatoid arthritis

Abdurakhmanova N.M., Alhmedov Kh.S., Botirbekov A.N.

dc.contributor.author	Abdurakhmanova N.M., Alhmedov Kh.S., Botirbekov A.N.
dc.date.accessioned	2023-06-13T06:09:55Z
dc.date.available	2023-06-13T06:09:55Z
dc.date.issued	2023
dc.identifier.citation	Тошкент	en_US
dc.identifier.uri	http://repository.tma.uz/xmlui/handle/1/8367
dc.description.abstract	Rheumatoid arthritis is a chronic, systemic, autoimmune inflammatory disease with a strong genetic contribution to its pathogenesis. The treatment response is influenced by several factors including differences in drug metabolism. Genetic factors may be responsible for up to 30 % of this difference. The MDR1 gene product, P-glycoprotein (P-gp), is probably one of the most important and best defined transporters for drug delivery in humans. A number of large cohort studies were conducted on the study of the C3435T polymorphism of the MDR1 (ABC1) gene in patients with RA, but very little data was available on studies of the presence of three isoforms of the ABC1 gene.	en_US
dc.language.iso	en	en_US
dc.subject	The aim of this study was examine genotype frequencies of the MDR1 gene C1236T (rs1128503), G2677T/A (rs2032582) and C3435T (rs1045642) polymorphisms in RA patients.	en_US
dc.title	The role of mdr1 gene polymorphism in the duration of remission of rheumatoid arthritis	en_US
dc.type	Thesis	en_US