MORPHOLOGICAL CHANGES IN THE VASCULAR TISSUE STRUCTURES OF T SMALL INTESTINE IN ACUTE EXPERIMENTAL INTESTINAL OBSTRUCTION

Abstract

: The purpose is to study the morphological state in the wall of the resected intestine during the development of intestinal insufficiency syndrome in animals with experimental intestinal obstruction. Materials and methods: experiment conducted on 60 white rats with average weight 170-190 g white rats. To create an experimental intestinal obstruction model in animals, an incision was made in the anterior lower part of the abdominal wall under ether anesthesia. 2 ligatures were placed at the top and bottom on the proximal part I-1.5 em from the ileocecal corner of the small imtestine. Then the abdominal wall was closed in layers. Results: The results obtained showed that in acute experimental intestinal obstruction, inflammatory and dystrophic changes are observed in the wall of the small intestine. Infiltration by mononuclear cells is detected in the tissue structures of the intestinal wall. In the intra-argan microvessels of the intestinal wall, there is swelling and swelling of the wall, a decrease in the internal diameter, stagnation, violation of the permeability of the walls, perivascular microextravasates and plasmorrhagia, a decrease in the density of the distribution of vessels. There are 3 stages in the development of these processes: compensatory, subcompensatory and decompensatory stages. The depth of these pathomorphological changes depends on the period and degree of development and compensation of the inflammatory process in the intestinal wall.