Prognostic role of biochemical markers in the diagnosis of anovulatory infertility in women associated with ovarian follicular cysts

Abstract

ABSTRACT Background. Anovulatory infertility represents one of the most common causes of infertility in women, characterised by the absence of ovulation. The aim of the study was to investigate the activity of the early marker of the inflammatory process, myeloperoxidase, in women with anovulatory infertility caused by ovarian follicular cysts. Materials. The study included 100 women with anovulatory infertility caused by ovarian follicular cysts, among them - 40 women with follicular cysts that developed against the background of chronic salpingo-oophoritis (Group I) and 40 women with follicular cysts that developed in the context of latent salpingo-oophoritis (Group II). The control group consisted of 20 healthy women. Results. The study results showed that myeloperoxidase levels were statistically significantly higher in Group I (with chronic salpingo-oophoritis) compared to Group II (with latent salpingo-oophoritis). Myeloperoxidase demonstrated high sensitivity (85%) and moderate specificity (60%) in predicting infertility caused by ovarian follicular cysts. Conclusion. The study results indicated that myeloperoxidase levels were statistically significantly higher in Group I compared to Group II. Myeloperoxidase demonstrated high sensitivity (85%) and moderate specificity (60%) in predicting infertility caused by ovarian follicular cysts. Plasma blood myeloperoxidase activity levels serve as a marker of inflammatory processes and can be used in the outpatient setting to refine the diagnosis and determine patient management strategies. Ovarian follicular cysts in women may be indicative of the presence of chronic inflammatory processes in the appendages of the uterus.