Abstract:
Aim – to determine the quantitative content of the tissue plasminogen
activator inhibitor type 1 (PAI-1) and to determine its relationship with
risk factors for coronary artery disease.
Material and methods. The study included 67 male and female patients
(36 men and 31 women) with coronary artery disease (CAD) and stable
angina classes II-IV with the presence of hypertension. The mean age of
the patients was 60.2±0.76 years. In all patients, clinical and anamnestic
data were collected during the examination. For pain assessment, we used
a verbal scale. We registered the anthropometric data and body mass index.
Biochemical and instrumental methods of research were used according
to the standards for diagnosing CAD. We assessed the occurrence of risk
factors in patients included in the study. A complex of general clinical
laboratory and instrumental tests was used, as well as the method of
enzyme immunoassay ELISA, which determined the level of PAI-1,
platelet aggregation activity, renin, aldosterone, cortisol and endothelin.Results. The group of patients demonstrated a reliable elevation of PAI-1
plasma level. Compared with practically healthy people, the level of this
biomarker was 1.6 times higher in patients with coronary artery disease. A
significant elevation of PAI-1 level indicates an increased risk of endothelial
and hemostasiological disorders in patients, which, in turn, increases the risk
of thrombogenic complications. The study revealed the correlation of PAI-1
protein in CAD patients with such risk factors as mixed anxiety-depressive
disorder, smoking, hypertension, obesity, and hypercholesterolemia.
