Abstract:
Researchers have shown that SARS-CoV and MERS-CoV can also cause liver damage in an infected organism, but the
mechanisms of injury are poorly understood. In this study, pathomorphological changes in the liver during coronavirus
infection in pregnant women were studied. As material, the liver was studied at autopsy of maternal mortality from 33
coronaviruses conducted at RCPA (Republican Center for Pathological Anatomy) between 2020 and 2021. Morphological
examinations of liver tissue showed that the development of various pathomorphological changes in the liver was also
observed depending on the periods of coronavirus infection. In the exudative period of the coronavirus is observed a strong
process of circulating in the liver, swelling, destruction and bleeding of interstitial tissue, the development of protein and
hydropic dystrophy in the liver parenchyma, i.e. hepatocytes. In the second proliferative inflammatory period of the
disease, there is an increase in lymphoid infiltration along the portal pathways of the liver, myxomatous metaplasia of
Kupffer cells, proliferation and proliferation of fibroblasts, growth of connective tissue, portal pathways of fibrous
structures, periphery and even sinusoidal wall.
