LIVER FUNCTION IN EXPERIMENTAL DIABETES MELLITUS AND WAYS OF ITS CORRECTION

Abstract

In diabetes mellitus, the provision of cells with the main substrates of plastic and energy metabolism and the activity of hepatocytes' intracellular enzyme systems are significantly disrupted. In this regard, the liver's functional capacity to maintain an adequate level of metabolites in the blood decreases, which affects the plastic and energy metabolism of other tissues, including the myocardium. Alcohol intake causes severe metabolic stress, so alcohol intoxication leads to an intensification of catabolic processes and can increase the metabolic disorders observed in diabetes mellitus. In the early period of alcohol intoxication caused in animals with experimental alloxan diabetes, signs of activation of the catabolism processes of nitrogencontaining compounds were found