Abstract:
In diabetes mellitus, the provision of cells with the main substrates of plastic and energy metabolism and the
activity of hepatocytes' intracellular enzyme systems are significantly disrupted. In this regard, the liver's
functional capacity to maintain an adequate level of metabolites in the blood decreases, which affects the
plastic and energy metabolism of other tissues, including the myocardium. Alcohol intake causes severe
metabolic stress, so alcohol intoxication leads to an intensification of catabolic processes and can increase the
metabolic disorders observed in diabetes mellitus. In the early period of alcohol intoxication caused in
animals with experimental alloxan diabetes, signs of activation of the catabolism processes of nitrogencontaining compounds were found
