Abstract:
The effectiveness of the medicine- Convaren for restoration of bile-forming function of liver was studied in
comparison with Celagrip, Lesbokhol, Liv.52, and Silibor on tetracycline induced acute hepatitis model. Experimental
studies were conducted on white male rats with an initial body weight of 170-200 g. The drug lesion was reproduced by daily
oral administration of tetracycline at a dose of 500 mg/kg into the stomach using a metal probe for 5 days. The animals were
treated with Celagrip (25 mg/kg), Lesbokhol (25 mg/kg), Convaren (50 mg/kg), Liv.52 (100 mg/kg), and Silibor (80 mg/kg)
for 6 days. Under the influence of Convaren, the excretion of bile increased by 48,2%, bile acids excretion increased by
89,6%, cholesterol by 94,8%, and bilirubin by 32,6% in tetracycline-induced hepatitis. Convaren showed a more significant
impact on the improvement of the bile-secretion activity of the liver in drug-induced hepatitis compared with Silibor, Liv.52,
Celagrip and Lesbokhol.
