Study of the Gastroprotective Activity of Some Derivatives of Glycyrrhetic Acid in Various Etiologic Damage of the Gastric Mucosa

Abstract

Improving the effectiveness of pharmacotherapy for diseases of the digestive system, including gastric ulcer (gastropathy) and duodenal ulcer is one of the pressing problems of gastroenterology. a comparative study of the effect on the gastric mucosa of derivatives of glycyrrhetic acid (18-dehydroglycyrrhetic acid - 18-DHA, 3-amino derivative of glycyrrhetic acid - 3-APGA, ammonium salt of glycyrrhetic acid - ASGA) in gastric lesions of various etiologies. The gastroprotective activity of 18-DHA, 3-APGA and ASGK was studied in white rats with various models of gastric mucosal lesions (GLC), as well as their effect on the intensity of free radical processes, the content of conjugated dienes and malondialdehyde was studied. Experimental studies have shown that 18-DHA, 3-APGK and ASGK in rats with different models of gastropathy clearly reduced the degree of damage to the coolant, manifested in a decrease in the number of strip-shaped-like and punctate erosions with a decrease in the Pauls index. In its pharmacological activity, 18-DHA was superior to other compounds. The mechanism of gastroprotective action is the presence of antioxidant properties in the studied compounds. 18-DHA can be recommended as a remedy for the prevention of lesions of the gastric mucosa.