Abstract:
Improving the effectiveness of pharmacotherapy for diseases of the digestive system, including gastric ulcer
(gastropathy) and duodenal ulcer is one of the pressing problems of gastroenterology. a comparative study of the effect on the
gastric mucosa of derivatives of glycyrrhetic acid (18-dehydroglycyrrhetic acid - 18-DHA, 3-amino derivative of glycyrrhetic
acid - 3-APGA, ammonium salt of glycyrrhetic acid - ASGA) in gastric lesions of various etiologies. The gastroprotective
activity of 18-DHA, 3-APGA and ASGK was studied in white rats with various models of gastric mucosal lesions (GLC), as
well as their effect on the intensity of free radical processes, the content of conjugated dienes and malondialdehyde was
studied. Experimental studies have shown that 18-DHA, 3-APGK and ASGK in rats with different models of gastropathy
clearly reduced the degree of damage to the coolant, manifested in a decrease in the number of strip-shaped-like and punctate
erosions with a decrease in the Pauls index. In its pharmacological activity, 18-DHA was superior to other compounds. The
mechanism of gastroprotective action is the presence of antioxidant properties in the studied compounds. 18-DHA can be
recommended as a remedy for the prevention of lesions of the gastric mucosa.
