Abstract:
Chronic kidney disease (CKD) is a generalized term that indicates damage to the renal tissue, regardless of the etiology of the underlying disease. CKD develops in every second patient with diabetes mellitus (DM) and significantly limits the duration and quality of life. CKD is diagnosed by the level of glomerular filtration rate (GFR), which is recognized as the most fully reflecting the number and total volume of nephrons. The article presents data on violations of the excretory and filtration functions of the kidneys, as well as lipid metabolism in patients with chronic kidney disease. The experience of the clinical use of the sacubitril/ valsartan combination in patients of this category is presented in order to study their effect on the functional state of the kidneys. The patients were divided into two groups. The first group of patients during treatment took sacubitril / valsartan 200 mg / day, the second group valsartan 160 mg / day. The functional state of the kidneys and heart was assessed on the basis of clinical and laboratory parameters. On the 30th day of treatment, these parameters were monitored. The positive effect of this combination on some biochemical parameters, blood lipid spectrum and renal function was noted.
