Abstract:
Despite ongoing therapeutic and preventive measures, chronic hepatitis of viral etiology still makes up a significant
proportion of extra genital pathology among women of childbearing age. On sexually mature female white outbred
rats before pregnancy, chronic heliothrine intoxication was created, leading to the development of chronic
aggressive hepatitis. The influence of maternal hepatitis on the structural and functional development and enzymatic
activity of the jejunum of the lean intestine o f the offspring during breastfeeding was researched. Morphological
studies have established that a decrease in the average number of villi on a transverse section of the intestine, a
decrease in the height of the villi, a decrease in the average number o f enterocytes (EC) on a transverse section of the
crypt, a decrease in the thickness of the mucous membrane and muscular-serous membranes progressing up to 15
days and a decrease in the height of the EC of the middle third o f the crypts to 7 days of development of rat pups. It
was also established a decrease in the average number o f EC on a longitudinal section of the crypt and villus, and a
decrease in the number of mitotically dividing cells up to 21 days of development. That is, structurally revealed a lag
in the development of the jejunum in the period of early postnatal ontogenesis, progressing to the transition of rat
pups to mixed and definitive nutrition. In functional researches in the offspring of females with chronic toxic
hepatitis, a delay in the natural age-dependent induction of the basal level of enteral enzymes: maltase, y-amylase,
sucrose and inhibition of lean intestine lactase during lactation was established. The authors believe that chronic
maternal hepatitis leads to lactase deficiency in the offspring, which can lead to widespread diarrhea and other
diseases of the gastrointestinal tract in children worldwide
