Abstract:
Uterine fibroids is the most common benign myometrial tumor,which affects approximately 20% of women over 30-35 years of age, is diagnosed more often in latereproductive age. Due to the fact that in some cases there is an asymptomatic course, the disease isdetected in 5 - 10% during routine examinations or ultrasound examination.Despite numerousstudies, proposals and implementation of new means and methods of treatment of uterine fibroids remainsthe most common gynecological pathology.The leading role in the development of uterine fibroids belongs to hyperestrogenism due tochanges in the metabolism of steroid hormones in the liver.The dyshormonal nature of the tumor determines the presence of a number of metabolic disorders,functional liver failure. In the formation of hormonal disorders, which are one of the main links in thepathogenesis of uterine fibroids, the liver is directly involved, actively participating in the metabolism ofestrogen. Of the numerous metabolic functions of the liver in uterine myoma, enzymatic inactivation andconjugation of steroid hormones with glucuronic and sulfuric acids are most often changed. Thiscircumstance is to a certain extent explained by the fact that in patients with uterine myoma, variousdiseases of the liver and biliary tract are often found, which contribute to the disruption of estrogen metabolism
