FEATURES OF IMMUNOBIOLOGICAL CORRECTION IN ONCOGYNECOLOGIC PATIENTS

Abstract

The aim of the study was to study the state of cellular and humoral factors of immunity in patients with cervical cancer against the background of immunocorrection, carried out by extracorporeal immunopharmacotherapy(EIPHT). Materials and Methods: 136 patients with cervical cancer T2-3N0-1M0 stages (II-III clinical stages) who were examined and treated in oncogynecology and chemotherapy departments of RSPMC of oncology and radiology and MOH RUz from 2004 to 2014 were included in the survey. Results:The analysis showed that patients with cervical cancer showed T-cell immunodeficiency, which was associated with CD4 + T-helper / inducer deficiency against the background of an increase in CD8 + T-lymphocytes and increased activation of lymphocytes with the predominance of apoptosis of immunocompetent cells. Conclusions. After carrying out extracorpoeral immunopharmacotherapy with thymalin, activation of the T-cell link of immunity is observed. The revealed imbalance of the humoral link of immunity before and after chemo- and radiotherapy was associated with an imbalance of the main serum immunoglobulins and an increased level of circulating immune complexes of small and large sizes.