Abstract:
The aim of the study was to study the state of
cellular and humoral factors of immunity in patients with cervical
cancer against the background of immunocorrection, carried out
by extracorporeal immunopharmacotherapy(EIPHT). Materials
and Methods: 136 patients with cervical cancer T2-3N0-1M0
stages (II-III clinical stages) who were examined and treated
in oncogynecology and chemotherapy departments of RSPMC
of oncology and radiology and MOH RUz from 2004 to 2014
were included in the survey. Results:The analysis showed that
patients with cervical cancer showed T-cell immunodeficiency,
which was associated with CD4 + T-helper / inducer deficiency
against the background of an increase in CD8 + T-lymphocytes
and increased activation of lymphocytes with the predominance
of apoptosis of immunocompetent cells. Conclusions. After
carrying out extracorpoeral immunopharmacotherapy with
thymalin, activation of the T-cell link of immunity is observed.
The revealed imbalance of the humoral link of immunity before
and after chemo- and radiotherapy was associated with an
imbalance of the main serum immunoglobulins and an increased
level of circulating immune complexes of small and large sizes.
