Abstract:
Parkinsonism is one of the most significant problems in clinical neurology, both due to its high
prevalence in the world's populations and due to the significant disability of patients. The paper
analyzes the diagnosis of Parkinson's disease (as well as other neurodegenerative diseases) at the
prodromal stage. An overview of the methods of preclinical and early clinical diagnosis of BP shows
that the study of the prmodromic markers and the criteria of the Premotor Phase Phase of the BP
will allow in the future to significantly change the course of the disease using neuroprotective
therapy at the stage preceding the death of a significant number of dopaminergic neurons of the
Black Substance.
