Molecular genetic features clinical course of chronic pancreatitis with external sekurity insufficiency

Abstract

Mutation of the N34S gene of the pancreatic secretory inhibitor of trypsin is detected significantly more often in patients with chronic pancreatitis than in healthy individuals, which is 9.2% and 2.8% respectively, while the homozygous for patients with HP also was greater – 5.4% and 0, 9%, respectively (p < 0.05), which suggests a significant role of these genetic changes in the development of chronic pancreatitis