Effect of Combined Therapy of Atorvastatin with Milk Thistle Extract on the Functional State of the Liver in Patients with CHD

Abstract

Coronary heart disease (CHD) remains the leading cause of death in industrialized countries and with a growing trend in developing countries. The most significant risk factor is hypercholesterolemia. While the most effective drug is statins. Statin therapy is usually well tolerated, but side effects may occur, including elevated liver enzymes, aminotransferases. In this regard, the appointment of statins, together with hepatoprotective drugs, such as: milk thistle extract reduces the side effects of lipid-lowering therapy in patients with CHD.