Abstract:
Aim. To assess the role of disorders of vasodilating, vasoconstrictor and adhesive functions of
the endothelium in the development of angina pectoris in patients with ischemic disease heart (CHD).
Material and methods. 93 patients with coronary heart disease were examined, 35 of them
with functional class II (FC) angina pectoris, 30 with FC III, 28 with FC IV. The control group
consisted of 23 healthy individuals. Bicycle ergometry, 24-hour ECG monitoring, and
echocardiography were used to verify IHD. The vasodilating function of the endothelium was
assessed by endothelium-dependent (EDVD) and endothelium-independent vasodilation (EIDVD) of
the brachial artery; vasoconstrictor function - by the level of endothelin-1 (ET-1). The adhesive
function of the endothelium was judged by the concentration of intercellular adhesion molecules
JCAM-1, VCAM-1, and E-selectin.
Results. With angina pectoris II FC, the indicators of EDVD and EIDVD, the level of ET-1 and
the content of intercellular molecules adhesions were within the normal range. As the FC of angina
pectoris increased, the vasodilating function of the endothelium was inhibited, and the production of
ET-1 and intercellular adhesion molecules increased. FC IV angina was characterized by
overexpression of JCAM-1, VCAM-1, E-selectin, excessive secretion of ET-1 at low levels of EDVD
and EIDVD.
Conclusion. The clinical course of coronary artery disease is associated with impaired
vasodilating, vasoconstrictor and adhesive functions endothelium.
