Abstract:
The purpose of the study. To evaluate multiparametric MRI for differentiation of benign and malignant soft tissue tumors.
Material and methods: This is a retrospective study of 67 patients (average age 55 years; 18-82 years) with 35 benign and 32 malignant soft tissue tumors. The parameters were compared between benign and malignant tumors.
Results: ADC and D were significantly lower in malignant than benign soft tissue tumors (1170 ± 488 vs. 1472 ± 349 mm2/s; 1132 ± 500 vs. 1415 ± 374 mm2/s; p <0.05). K trans , K ep, V e and iAUC significantly differed between malignant and benign soft tissue tumors (0.209 ± 0.160 vs. 0.092 ± 0.067 min -1; 0.737 ± 0.488 vs. 0.311 ± 0.230 min -1 ; 0.32 ± 0.17 vs. 0.44 ± 0.28; 0.23 ± 0.14 vs. 0.12 ± 0.09, p <0.05, respectively). ADC (0.752), D (0.742) and ep (0.817) had high AUC. Subgroup analysis showed that only K-trans and iAUC differed significantly in myxoid tumors, while ADC, D, K-trans, K ep and iAUC differed significantly in non-myxoid tumors to differentiate benign and malignant tumors. D, K ep and iAUC were the most significant, predictable malignant soft tissue tumors.
Conclusion: Multiparametric MRI can be useful for differentiating benign and malignant soft tissue tumors using IVIM-DWI and DCE-MRI.
