Abstract:
Resume. Relevance: Premature ejaculation (PE)
remains a complex polyetiological disease destabilizing
the sexual function of men. Its prevalence is estimated at
20-40%. The diagnosis of PE is difficult because its
symptoms are largely subjective and poorly defined in
the clinical context. Pharmacotherapy is used as the main
method of therapy.
Objective: Comparative evaluation of the efficacy
and safety of Clomipramine hydrochloride (2.5 mg nasal
spray) and Fluoxetine (20 mg capsules) in the treatment
of patients with premature ejaculation.
Methods: The study involved 672 men aged 18 to 60
years (average age 36.4±3.7 years) with complaints of
PE. The respondents were surveyed using the ques tionnaire “Uzbek PE Index" (UIPE). 101 patients were
selected by random sampling to evaluate the effective ness and safety of a nasal spray containing Clomipramine
hydrochloride. 103 patients were examined and treated
with fluoxetine. 99 patients were in the placebo group.
Results: in patients with premature ejaculation
treated with clomipramine, LIVIA increases compared to
patients treated with fluoxetine.
