Abstract:
determination of the pathophysiological validity of the use of the new amino acid
mixture for damage to the liver.Materials methods. Acute heliotrin intoxication is reproduced
by single administration of rats subcutaneous sub-lethal doses of heliotrin, prepared at the rate
of 40 mg per 100 g of body weight. Toxic hepatitis is reproduced by subcutaneous administration
of heliotrin. Results. During the reproduction of experimental toxic hepatitis by introducing
heliotrin, it was found that the HIF-1 content was on average 0.101667 ± 0.0022 ng /l. In blood
plasma, the average HIF-1 was 0.2136 ± 0.0066 ng / L. Such indicators are explained by the
effect of heliotrin on the liver and, above all, on hepatocytes, in which mitochondria are
experiencing an oxygen deficiency. Thus, HIF-1 acts as an early biomarker of oxygen tissue
deficiency and since it causes angiogenesis, the strengthening of this gene in experimental
animals with ischemia can contribute to the proliferation of vessels necessary for oxygenation.
Conclusions: The developed aminoacid mixture in terms of the effectiveness of the impact on
the development and course of experimental toxic hepatitis surpasses traditional methods of
treatment, which is proved by the study
