Abstract:
Objective: to study enzymes of different localization of hepatocytes in endogenous
intoxication in patients with chronic liver diseases.
Material and methods: in patients with chronic liver diseases, the activity of
hepatocyte enzymes, as well as marker enzymes of mitochondria, was determined.
Results: in patients with chronic diffuse liver diseases, against the background of the
formation of reactive oxygen species and endogenous intoxication, hyperenzymemia was
noted due to a violation of the membrane structures of hepatocyte mitochondria, as well as
stimulation of macrophages in the liver, which was expressed in an increase in the
concentration of cystatin C and cathepsin B in the blood. An increase in the activity of the
lysosomal enzyme cathepsin B may be one of the reasons for the death of hepatocytes and
the acceleration of apoptosis. Conclusions: in patients with chronic liver disease, against
the background of endogenous intoxication and an increase in lipid peroxidation products,
cytolytic damage to hepatocytes and hyperfermentemia occur.
