The study of lipid spectrum and markers of vascular inflammation in patients with stable angina pectoris with diabetes mellitus

Abstract

In recent decades, the role of a chronic inflammatory process in the development of cardiovascular complications in patients with coronary artery disease and diabetes has been actively discussed. Target. study of markers of the vascular inflammatory process in patients with coronary artery disease in combination with type 2 diabetes. Identify a set of laboratory parameters that can become predictors of cardiovascular complications. Materials and methods. We examined 69 patients aged 60.3±9.8 years with coronary artery disease, stable exertional angina. Patients are divided into 2 groups. Group 1 - patients with IHD (n=30), Group 2 - IHD with type 2 diabetes (n=39). Results. The study of laboratory parameters of blood serum was carried out against the background of standard therapy before and after 12±2.4 months of observation. Initially, in the 2nd group of patients, a significant excess of the level of atherogenic parameters of the lipid profile (total cholesterol, VLDL, TG) and markers of inflammation (highly sensitive C-reactive protein, fibrinorgen ) was revealed compared to the 1st group.