Abstract:
This analysis examines data from authoritative sources, as well as some data
without changes and citations. A review of 1,3,4-oxadiazole derivatives shows a high potential
for their antimicrobial activity. The new structures have a very wide range of activity, from
bacteria and fungi to protozoa and viruses. The possible mechanisms of action of some of the
new compounds, which are based on the inhibition of various enzymes, for example, DNA
gyrase, enoyl reductase and lanosterol-14α-demethylase, are described. Many of the new
derivatives exceed the activity of already known antimicrobials. The variety of new structures
and their high activity confirm their value as new drugs in the fight against antimicrobial
resistance. Further studies are needed to confirm their efficacy and safety in vivo. The
development of antimicrobial resistance around the world is forcing scientists to look for new
compounds to which microbes would be sensitive. Many new structures contain a 1,3,4-
oxadiazole ring, which exhibit various antimicrobial activity, for example, antibacterial,
antituberculous, antifungal, antiprotozoal and antiviral. In many publications, the activity of
new compounds exceeds the activity of already known antibiotics and other antimicrobials, so
their potential as new drugs is very promising. The review of active antimicrobial derivatives
of 1,3,4-oxadiazole is based on the literature for the period last 5 - 6 years.Thus, several
conclusions can be drawn regarding the relationship between structure and activity. In the
amino derivatives of 1,3,4-oxadiazole, it can be seen that the additional presence of another
heterocyclic ring can expand the spectrum of antimicrobial activity.
