Clinical and Neurological Disorders in Systemic Vasculitis in Children

Abstract

Systemic vasculitis (SV) is a systemic autoimmune disease of unknown etiology, pathogenetically associated with immunoregulatory disorders that cause hyperproduction of a wide range of organ-nonspecific autoantibodies to various components of the nucleus and immune complexes, causing immuno-inflammatory damage to blood vessels and dysfunction of internal organs [1, 6,8,9,10]. Vasculitis is characterized by multivariable manifestations, course and prognosis, exacerbations and remissions. Potential targets for immune aggression can be a variety of antigens of the nervous tissue [1, 2, 7]. Studies conducted in recent years have proven the commonality and interconnection of the nervous and immune systems, and the results of experimental developments have confirmed the similarity between their structures and functions, which contributed to the development of a new direction - neuroimmunology