Abstract:
Today, amid the ongoing COVID-19 pandemic, it has become clear that SARS-CoV-2
infection can have long-term consequences, even after asymptomatic or mild acute cases, raising
concerns about the consequences of COVID-19. The terms “long-COVID-19”, “chronic
COVID-19”, “post-COVID-19 syndrome” have appeared. Patients who have had COVID-19
often have fatigue, cognitive and psycho-emotional disorders, which are often referred to as
"brain fog", and the possibility of developing neurodegenerative diseases is also discussed. The
exact pathophysiological mechanisms of the development of the neurological long-term
consequences of COVID-19 have not been established, but at the same time, numerous links are
emerging between the post-COVID-19 syndrome, immunological changes, and
neurotransmission dysfunction in the brain. Using method of immunochemical analysis ELI Neuro-Test, developed by Professor A.B. Poletaev, we analyzed an individual profile of serum
immunoreactivity, depending on changes in the relative content of IgG autoantibodies directed to
12 autogens of the nervous system. We identified in patients who underwent COVID-19
immunochemical signs of damage to the GABAergic (58.6%), opioid (37.9%), serotonergic
(20.7%), cholinergic (13.8%) neurotransmitter systems, and also markers of axonal damage
(20.7%), demyelination (10.3%) and reactive astrogliosis (24.1%). However, given the small
sample size, further research is required.
