Abstract:
Systemic sclerosis (SSc) is one of the most serious health problems imparing
quality of life of patients due to physical disabilities and cause considerable financial burden on patients and health resources. SSc is a chronic autoimmune connective tissue disease, characterized by endothelial dysfunction, immune abnormalities and progressive fibrosis of skin and multiple inner organs. According to the last data, 18,87 per 100 000 people (1.55–25.28) and overall 1.47 million (0.12–1.97) people in the world suffer from SSc.
