Abstract:
Given its important function, the manipulation of HIF-1 activity in areas of
ischemia and tumor masses has become a major focus of efforts to develop non-
invasive, pharmaceutical treatment options for patients with cancer and heart
disease. Although no such human protein has been successfully regulated by
scientific methods, control of HIF-1 activity is becoming increasingly feasible as
the details of its structure, function, and genetic pathway are elucidated.
