Abstract:
We have studied the association of MTRR polymorphism (rs1801394) with the risk of
developing rheumatoid arthritis among the population of Uzbekistan. The assessment of
this genetic polymorphism was carried out by analyzing DNA samples by standard PCR.
The results of the study we obtained made it possible to establish the correspondence
between the differences between the expected and observed frequencies of the
genotype variants of the MTRR (rs1801394) gene polymorphism for RHB (p>0.05) both
in the group of patients and in the comparison group. The proportion of occurrence of
unfavorable allele (G) and genotypes (A/G and G/G) in the general group of patients
with RA and among patients with the articular form of the disease does not significantly
differ from those in the control (χ2<3.84; Р>0.05). Only among patients with the
articular-visceral form, there is a tendency to increase the occurrence of the A/G
genotype by 1.6 times (χ2=1.3; P=0.262; OR=1.6; 95% CI: 0.716-3.504). Perhaps, with a
larger coverage of the examined RA, a significant relationship with the development of
the articular-visceral form of the disease could be established.
