Abstract:
In order to assess immunopathological changes in children with nephrotic syndrome with underlying pathology, 120 children
aged 7 to 11 years were examined. Of these: group 1 - 35 children with NS (nephrotic form of CGN); group 2 - 35 children
with NS against the background of LD; group 3 - 25 children with LD. Healthy group: 25 practically healthy children of the
same age. It was determined that in children with nephrotic syndrome (nephrotic form of chronic glomerulonephritis) occurring
with underlying pathology (lymphatic diathesis), specific clinical symptoms are characteristic, such as increased edema
(100.0%), oliguria (100.0%), "chalky" pallor (74.2%), anasarca (9.0%) and hepatosplenomegaly (57.1%), in parallel with this,
the development of sever e anemia, a decrease in cortisol, an increase in lymphocytosis, proteinuria, fibrinogen, gamma
globulin and cholesterol, contributing to the development of steroid-dependent and steroid-resistant forms of the disease. In
nephrotic syndrome with lymphatic diathesis, a deficiency of the cellular link of immunity, a violation of the production of the
cytokine IL-2, an increase in the content of ABL-kidneys, ABL-lungs, which remain preserved even in the period of remission
of the disease, are characteristic, which confirm that in the treatment of such contingents of patients it is necessary to include
in therapy adequate methods of immunocorrection.
