Abstract:
Purpose of the study. To study the features of the frequency distribution of alleles and
genotypes of IL-1β (rs1143627) gene polymorphism, its role in the development of ITP in people of the Uzbek ethnic group. Material and methods: The study included 89 patients with ITP (median age - 41 ± 1.7 years) (main group) who were admitted for examination by the RSPMCH in the period from 2012 to 2018. Detection of IL-1β (rs1143627) polymorphism was carried out by SNP-PCR. Results and its discussion. Carriage of the IL-1β gene polymorphism (rs1143627) is not associated with the risk of developing immune thrombocytopenia.
