Prediction of COVID-19 manipulation by selective ACE inhibitory compounds of Potentilla reptant root: In silico study and ADMET profile

Yuan Xu, Mahmood Al-Mualm,  Ermias Mergia Terefe, Maksuda Ilyasovna Shamsutdinova, Maria Jade Catalan Opulencia, Fahad Alsaikhan, Abduladheem Turki Jalil, Ali Thaeer Hammid, Ayesheh Enayati, Hassan Mirzaei i, Vahid Khori i , Ali Jabbari i , Aref Salehi i, Alireza Soltani, Abdullah Mohamed

Prediction of COVID-19 manipulation by selective ACE inhibitory compounds of Potentilla reptant root: In silico study and ADMET profile

Yuan Xu, Mahmood Al-Mualm, Ermias Mergia Terefe, Maksuda Ilyasovna Shamsutdinova, Maria Jade Catalan Opulencia, Fahad Alsaikhan, Abduladheem Turki Jalil, Ali Thaeer Hammid, Ayesheh Enayati, Hassan Mirzaei i, Vahid Khori i , Ali Jabbari i , Aref Salehi i, Alireza Soltani, Abdullah Mohamed

URI: http://repository.tma.uz/xmlui/handle/1/5336

Date: 2022

Abstract:

In the novel SARS-CoV-2 (COVID-19) as a global emergency event, the main reason of the cardiac injury from COVID-19 is angiotensin-converting enzyme 2 (ACE2) targeting in SARS- CoV-2 infection. The inhibition of ACE2 induces an increase in the angiotensin II (Ang II) and the angiotensin II receptor type 1 (AT1R) leading to impaired cardiac function or cardiac inflammatory

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