Experimental substantiation of the use of hypoxia-inducible factor (hif-1α) for the development of toxic hepatitis.

Abstract

This article provides an experimental rationale for the use of hypoxia-inducible factor (HIF-1α) for the development and course of toxic hepatitis based on heliotrin intoxication. Acute heliotrin intoxication was reproduced by a single subcutaneous administration of a sublethal dose of heliotrin to rats, prepared at the rate of 40 mg per 100 g of body weight. During the reproduction of experimental toxic hepatitis by the introduction of heliotrin, it was found that the HIF-1 content was on average 0.101667 ± 0.0022 ng / L. In blood plasma, the mean HIF-1 values were 0.2136 ± 0.0066 ng / L.